Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer.

@article{Trinder1999ConstitutiveAI,
  title={Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer.},
  author={Peter K.E. Trinder and Ulrike Seitzer and Johannes Gerdes and Barbara Seliger and Markus Maeurer},
  journal={International journal of oncology},
  year={1999},
  volume={14 1},
  pages={23-31}
}
Although not structurally related, the pleiotropic cytokines interleukin-7 (IL-7) and interleukin-15 (IL-15) share a variety of biological functions including stimulation and maintenance of cellular immune responses. Cytokines, such as IL-7 or IL-15, elaborated by cells in situ, e.g. cancer cells, may be involved in shaping the quality of anti-tumor directed immune responses. We have analysed the constitutive and IFN-gamma-inducible expression of IL-15 or IL-7 mRNA, protein expression, and… CONTINUE READING

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