Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.

@article{Magdalon2016ConstitutiveAM,
  title={Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.},
  author={Juliana Magdalon and Patr{\'i}cia Chimin and Thiago Belchior and Rodrigo Xavier das Neves and Marcel A. Vieira-Lara and Maynara L. Andrade and Talita da S.M. Farias and Andressa Bolsoni-Lopes and Vivian Almeida Paschoal and Alex Shimura Yamashita and Alicia J Kowaltowski and William Festuccia},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1861 5},
  pages={
          430-8
        }
}
Mechanistic target of rapamycin complex 1 (mTORC1) loss of function reduces adiposity whereas partial mTORC1 inhibition enhances fat deposition. Herein we evaluated how constitutive mTORC1 activation in adipocytes modulates adiposity in vivo. Mice with constitutive mTORC1 activation in adipocytes induced by tuberous sclerosis complex (Tsc)1 deletion and littermate controls were evaluated for body mass, energy expenditure, glucose and fatty acid metabolism, mitochondrial function, mRNA and… CONTINUE READING
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