Constitutive activity of neural melanocortin receptors.

  title={Constitutive activity of neural melanocortin receptors.},
  author={Ya-Xiong Tao and Hui Huang and Zhirong Wang and Fan Yang and Jessica N Williams and Gregory V. Nikiforovich},
  journal={Methods in enzymology},
The two neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), are G protein-coupled receptors expressed primarily in the brain that regulate different aspects of energy homeostasis. The MCRs are unique in having endogenous antagonists, agouti and agouti-related protein (AgRP). These antagonists were later shown to be inverse agonists. The MC3R has little or no constitutive activity, whereas the MC4R has significant constitutive activity that can easily be… CONTINUE READING

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