Constitutive activity of a chimeric D2/D1 dopamine receptor.

@article{Kozell1997ConstitutiveAO,
  title={Constitutive activity of a chimeric D2/D1 dopamine receptor.},
  author={Laura B. Kozell and Kim A Neve},
  journal={Molecular pharmacology},
  year={1997},
  volume={52 6},
  pages={
          1137-49
        }
}
Chimeric D1/D2 receptors were constructed to identify structural determinants of drug affinity and efficacy. We previously reported that chimeras that had D1 receptor transmembrane domain VII together with amino-terminal sequence from the D2 receptor were nonfunctional. D2/D1 chimeras were constructed that contained D2 receptor sequence at the amino- and carboxyl-terminal ends and D1 receptor sequence in the intervening region. Chimeric receptors with D2 sequence from transmembrane domain 7 to… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Molecular biology of dopamine receptors, in The Dopamine Receptors (K

K. A. Neve, R. L. Neve
  • eds.). Humana Press, Totawa, NJ,
  • 1997
VIEW 1 EXCERPT