Constitutive activation of the Wnt/β-catenin signalling pathway in acute myeloid leukaemia

@article{Simon2005ConstitutiveAO,
  title={Constitutive activation of the Wnt/β-catenin signalling pathway in acute myeloid leukaemia},
  author={Maria T. Simon and Victoria L Grandage and David Christopher Linch and Asim A. Khwaja},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2410-2420}
}
The β-catenin protein is at the core of the canonical Wnt signalling pathway. Wnt stimulation leads to β-catenin accumulation, nuclear translocation and interaction with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors to regulate genes important for embryonic development and proliferation. Wnt/β-catenin can promote stem cell self-renewal and is dysregulated in colon carcinoma. We have examined the role of the Wnt pathway in the development of acute myeloid leukaemia (AML… CONTINUE READING
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