Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.

@article{Wong2015ConstitutiveAO,
  title={Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.},
  author={Sophie Y. Wong and Theresa A. Ulrich and Loic P. Deleyrolle and Joanna L Mackay and J G Lin and Regina T. Martuscello and Musa A Jundi and Brent A Reynolds and S. Kiran Kumar},
  journal={Cancer research},
  year={2015},
  volume={75 6},
  pages={1113-22}
}
Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known about the role of mechanotransductive signaling in controlling TIC tumorigenesis, despite the recognized importance of altered mechanics in tissue dysplasia and the common observation that extracellular matrix (ECM) stiffness strongly regulates cell behavior. To address this open question, we cultured primary human glioblastoma (GBM) TICs on… CONTINUE READING
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