Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest.

@article{Park2000ConstitutiveAO,
  title={Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest.},
  author={Mi-kyung Park and Hee Dong Chae and J Yun and Mira Jung and Young Sik Kim and Sun Ran Kim and Moon Hi Han and Deug Y. Shin},
  journal={Cancer research},
  year={2000},
  volume={60 3},
  pages={542-5}
}
Recent studies have suggested that p53 regulates the G2 checkpoint in the cell cycle and that this function is required for the maintenance of genomic integrity. In this study, we investigated a regulatory role of p53 specifically in G2-M transition. Human bladder carcinoma cells lacking functional p53 were synchronized at G1-S, which is preceded by p53-mediated G1 arrest. p53 expression in the synchronized cells was induced by infection with a recombinant adenovirus that encodes p53. After… CONTINUE READING

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