Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

@article{Harir2007ConstitutiveAO,
  title={Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.},
  author={Noria Harir and Christian Pecquet and Marc Ker{\'e}nyi and Karoline Sonneck and Boris Kovacic and R{\'e}my Nyga and M. A. J. Brevet and Isabelle Dhennin and V. Gouilleuxgruart and Hartmut Beug and Peter Valent and Kaiss Lassoued and Richard Moriggl and Fabrice Gouilleux},
  journal={Blood},
  year={2007},
  volume={109 4},
  pages={
          1678-86
        }
}
Persistent activation of Stat5 is frequently found in hematologic neoplasms. Studies conducted with constitutively active Stat5 mutants (Stat51*6 and cS5F) have shown that deregulated Stat5 activity promotes leukemogenesis. To investigate the oncogenic properties of these mutants, we used cS5F-expressing bone marrow cells which induce a multilineage leukemia when transplanted into recipient mice. Here, we show by immunocytochemistry that cS5F is localized mainly in the cytoplasmic compartment… CONTINUE READING

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