Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.

@article{Zhang2006ConstitutiveAO,
  title={Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.},
  author={R. D. Zhang and Shunichi Murakami and Françoise Coustry and Ying Wang and Benoit de Crombrugghe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 2},
  pages={365-70}
}
Accumulating in vitro evidence suggests that the p38 mitogen-activated protein kinase (MAPK) pathway is involved in endochondral ossification. To investigate the role of this pathway in endochondral ossification, we generated transgenic mice with expression in chondrocytes of a constitutively active mutant of MKK6, a MAPK kinase that specifically activates p38. These mice had a dwarf phenotype characterized by reduced chondrocyte proliferation, inhibition of hypertrophic chondrocyte… CONTINUE READING

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