Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.

@article{Kersseboom2010ConstitutiveAO,
  title={Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.},
  author={Rogier Kersseboom and Laurens P. Kil and Roelof Flierman and Marten van der Zee and Gemma M. Dingjan and Sabine Middendorp and Alex Maas and Rudi W Hendriks},
  journal={European journal of immunology},
  year={2010},
  volume={40 9},
  pages={2643-54}
}
B-cell receptor (BCR)-mediated signals provide the basis for B-cell differentiation in the BM and subsequently into follicular, marginal zone, or B-1 B-cell subsets. We have previously shown that B-cell-specific expression of the constitutive active E41K mutant of the BCR-associated molecule Bruton's tyrosine kinase (Btk) leads to an almost complete deletion of immature B cells in the BM. Here, we report that low-level expression of the E41K or E41K-Y223F Btk mutants was associated with reduced… CONTINUE READING
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