Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

@article{Brandts2005ConstitutiveAO,
  title={Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.},
  author={C. Brandts and B. Sargin and M. Rode and C. Biermann and B. Lindtner and J. Schwaeble and H. Buerger and C. M{\"u}ller-Tidow and C. Choudhary and M. McMahon and W. Berdel and H. Serve},
  journal={Cancer research},
  year={2005},
  volume={65 21},
  pages={
          9643-50
        }
}
  • C. Brandts, B. Sargin, +9 authors H. Serve
  • Published 2005
  • Biology, Medicine
  • Cancer research
  • Up to 30% of patients with acute myeloid leukemia (AML) harbor internal tandem duplications (ITD) within the FLT3 gene, encoding a receptor tyrosine kinase. These mutations induce constitutive tyrosine kinase activity in the absence of the natural Flt3 ligand and confer growth factor independence, increased proliferation, and survival to myeloid precursor cells. The signaling pathways and downstream nuclear targets mediating leukemic transformation are only partly identified. Here, we show that… CONTINUE READING
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