Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

@inproceedings{Ohnmacht2009ConstitutiveAO,
  title={Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity},
  author={Caspar Ohnmacht and Andrea Pullner and Susan B. S. King and Ingo Drexler and Stefanie Meier and Thomas Brocker and David Voehringer},
  booktitle={The Journal of experimental medicine},
  year={2009}
}
Lack of immunological tolerance against self-antigens results in autoimmune disorders. During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-reactive T cells that have escaped tolerance induction. However, because DCs can also induce T cell tolerance, it remains unclear whether DCs are required under steady-state conditions to prevent autoimmunity. To address this question, we crossed CD11c-Cre mice with mice that express diphtheria toxin A (DTA… CONTINUE READING
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