Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra.

@article{Mijatovi2007ConstitutiveRA,
  title={Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra.},
  author={Jelena Mijatovi{\'c} and Mikko Airavaara and Anu Planken and Petri Auvinen and Atso Raasmaja and T Petteri Piepponen and Frank D. Costantini and Liisa Ahtee and Mart Saarma},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 18},
  pages={4799-809}
}
Ret is the common signaling receptor for glial cell line-derived neurotrophic factor (GDNF) and other ligands of the GDNF family that have potent effects on brain dopaminergic neurons. The Met918Thr mutation leads to constitutive activity of Ret receptor tyrosine kinase, causing the cancer syndrome called multiple endocrine neoplasia type B (MEN2B). We used knock-in MEN2B mice with the Ret-MEN2B mutation to study the effects of constitutive Ret activity on the brain dopaminergic system and… CONTINUE READING

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The mouse brain in stereotaxic coordinates

  • K Franklin, G Paxinos
  • San Diego: Academic
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