Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability

@article{Park2007ConstitutiveRA,
  title={Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability},
  author={Minsun Park and Yeryoung Yong and Seung-Won Choi and Jae Hwan Kim and Jong Eun Lee and Dae-Won Kim},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={287-298}
}
During endochondral ossification, a process that accounts for the majority of bone formation in vertebrates, hypertrophic chondrocytes display a greater susceptibility to apoptosis when compared to proliferating chondrocytes. However, the molecular mechanisms underlying this phenomenon remain unclear. Nkx3.2, a member of the NK class of homeoproteins, is initially expressed in chondrogenic precursor cells, and later, during cartilage maturation, its expression is restricted to proliferating… CONTINUE READING
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