Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice.

@article{Grtner2004ConstitutiveRA,
  title={Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice.},
  author={Ulrich G{\"a}rtner and Al{\'a}n Alp{\'a}r and F Reimann and G. Seeger and Rolf Heumann and Thomas Arendt},
  journal={Journal of neuroscience research},
  year={2004},
  volume={77 5},
  pages={630-41}
}
The small G protein Ras, which is involved critically in neurotrophic signal transduction, has been implicated in neuronal plasticity of both the developing and the adult nervous systems. In the present study, the cumulative effects of constitutive Ras activity from early in postnatal development into the adult upon the morphology of hippocampal pyramidal… CONTINUE READING