Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.

@article{Dalton2013ConstitutiveRA,
  title={Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.},
  author={Lucy E. Dalton and J. Kamarashev and I. Barinaga-Rementeria Ramirez and G. White and A. Malliri and A. Hurlstone},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 6},
  pages={
          1572-81
        }
}
  • Lucy E. Dalton, J. Kamarashev, +3 authors A. Hurlstone
  • Published 2013
  • Medicine, Biology
  • The Journal of investigative dermatology
  • Deregulated Ras signaling initiates and maintains melanocyte neoplasia. The Rho-like GTPase Rac has been implicated in Ras-induced neoplastic transformation. Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detected in human melanoma. Here, a role for Rac in melanoma initiation and progression was investigated in human melanomas and zebrafish models of melanocyte neoplasia. Immunohistochemical analysis revealed RAC expression and activity restricted to melanocytes at… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES
    Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation.
    • 694
    • Open Access
    An essential role for Rac in Ras transformation
    • 890
    BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma
    • 554
    • Open Access
    Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • 377
    • Open Access
    A Landscape of Driver Mutations in Melanoma
    • 1,765
    • Open Access
    Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • 864
    • Highly Influential
    • Open Access
    Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
    • 88
    • Open Access
    Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism
    • 56
    • Highly Influential
    • Open Access