Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.

@article{Dalton2013ConstitutiveRA,
  title={Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.},
  author={Lucy E. Dalton and Jivko Kamarashev and Irene Barinaga-Rementeria Ramirez and Gavin R. M. White and Angeliki Malliri and Adam F. L. Hurlstone},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 6},
  pages={1572-81}
}
Deregulated Ras signaling initiates and maintains melanocyte neoplasia. The Rho-like GTPase Rac has been implicated in Ras-induced neoplastic transformation. Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detected in human melanoma. Here, a role for Rac in melanoma initiation and progression was investigated in human melanomas and zebrafish models of melanocyte neoplasia. Immunohistochemical analysis revealed RAC expression and activity restricted to melanocytes at… CONTINUE READING