Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

@article{Murata2002ConstitutiveOL,
  title={Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.},
  author={Kazuko Murata and Masato Nose and Lishomwa C. Ndhlovu and Takayuki Sato and Kazuo Sugamura and Naoto Ishii},
  journal={Journal of immunology},
  year={2002},
  volume={169 8},
  pages={
          4628-36
        }
}
The interaction between OX40 and OX40 ligand (OX40L) is suggested to provide T cells with an effective costimulatory signals during T cell-APC interaction. To examine the in vivo effect of constitutive OX40/OX40L interaction during immune regulation, we report the establishment of OX40L-transgenic (OX40L-Tg) mice that constitutively express OX40L on T cells. Markedly elevated numbers of effector memory CD4(+) T cells, but not CD8(+) T cells, were observed in the secondary lymphoid organs of… CONTINUE READING
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