Constitutive NF-κB and NFAT Activation Leads to Stimulation of The BLyS Survival Pathway in Aggressive B Cell Lymphomas

Abstract

B-lymphocyte stimulator (BLyS), a relatively recently recognized member of the tumor necrosis factor ligand family (TNF), is a potent cell-survival factor expressed in many hematopoietic cells. BLyS binds to 3 TNF-R receptors, TACI, BCMA, BAFF-R, to regulate B-cell survival, differentiation, and proliferation. The mechanisms involved in BLYS gene expression… (More)

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@inproceedings{Fu2006ConstitutiveNA, title={Constitutive NF-κB and NFAT Activation Leads to Stimulation of The BLyS Survival Pathway in Aggressive B Cell Lymphomas}, author={Lingchen Fu and Yen-chiu Lin-Lee and Lan V. Pham and Archito T. Tamayo and Linda C. Yoshimura and Richard J. Ford and M. D. Anderson}, year={2006} }