Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

Abstract

In the present study, we aimed to elucidate the mechanism responsible for constitutive NF-κB DNA-binding activity in AML cells. Intervening in aberrant signaling pathway provides a rational approach for in vivo targeting of AML cells. Constitutive NF-κB DNA-binding activity was observed in 16 of 22 (73%) investigated AML cases and was, in general… (More)
DOI: 10.1038/sj.leu.2403145

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