Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression.

@article{Tephly2007ConstitutiveNO,
  title={Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression.},
  author={Linda A. Tephly and Aaron Brent Carter},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 5},
  pages={L1143-55}
}
Alveolar macrophages, which generate high levels of reactive oxygen species, especially O(2)(*-), are involved in the recruitment of neutrophils to sites of inflammation and injury in the lung, and the generation of chemotactic proteins triggers this cellular recruitment. In this study, we asked whether O(2)(*-) generation in alveolar macrophages had a role in the expression of chemokines. Specifically, we hypothesized that O(2)(*-) generation is necessary for chemokine expression in alveolar… CONTINUE READING
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