Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus.

@article{Hata2001ConstitutiveIS,
  title={Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus.},
  author={Nobuhiko Hata and Mitsuharu Sato and Akinori Takaoka and Masataka Asagiri and Nobuyuki Tanaka and Tomoyasu Taniguchi},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={285 2},
  pages={518-25}
}
Efficient IFN-alpha/beta gene induction in virus-infected cells is an event central to innate immunity, in which the transcription factor IRF-7 plays a critical role together with IRF-3. Unlike IRF-3, IRF-7 is short-lived and its gene expression is dependent on IFN-alpha/beta signalling; hence, the signal-dependent enhancement of IRF-7 gene induction during viral infection is essential for positive-feedback regulation of IFN-alpha/beta gene induction. Here, we provide evidence that constitutive… CONTINUE READING