Constitutive Expression of Interferon-Induced Human MxA Protein in Transgenic Tobacco Plants Does not Confer Resistance to a Variety of RNA Viruses

@article{Frese2000ConstitutiveEO,
  title={Constitutive Expression of Interferon-Induced Human MxA Protein in Transgenic Tobacco Plants Does not Confer Resistance to a Variety of RNA Viruses},
  author={Michael Frese and Marcel Prins and Annette Ponten and R. W. Goldbach and Otto Haller and Patric Zeltz},
  journal={Transgenic Research},
  year={2000},
  volume={9},
  pages={429-438}
}
MxA is a key component in the interferon-induced antiviral defense in humans. After viral infections, MxA is rapidly induced and accumulates in the cytoplasm. The multiplication of many RNA viruses,including all bunyaviruses tested so far, is inhibited by MxA. These findings prompted us to express MxA in plants in an attempt to create resistance to tospoviruses. Here, we report the generation of transgenic tobacco plants that constitutively express MxA under the control of the 35 S cauliflower… CONTINUE READING
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Highly Influential
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