Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor

  title={Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor},
  author={Maddalena Panigada and Simona Porcellini and Eliane Barbier and Sonja Hoeflinger and P. -A. Cazenave and Hua Gu and Hamid Band and Harald von Boehmer and Fabio Grassi},
  journal={The Journal of Experimental Medicine},
  pages={1585 - 1597}
The pre-T cell receptor (TCR) signals constitutively in the absence of putative ligands on thymic stroma and signal transduction correlates with translocation of the pre-TCR into glycolipid-enriched microdomains (rafts) in the plasma membrane. Here, we show that the pre-TCR is constitutively routed to lysosomes after reaching the cell surface. The cell-autonomous down-regulation of the pre-TCR requires activation of the src-like kinase p56(lck), actin polymerization, and dynamin. Constitutive… CONTINUE READING

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