Constitutive EGFR signaling confers a motile phenotype to neural stem cells.

  title={Constitutive EGFR signaling confers a motile phenotype to neural stem cells.},
  author={J A Boockvar and Dmitri Kapitonov and Gurpreet Singh Kapoor and J W Schouten and George J Counelis and Oliver Bogler and Evan Yale Snyder and T K Mcintosh and Donald M. O'Rourke},
  journal={Molecular and cellular neurosciences},
  volume={24 4},
The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but… CONTINUE READING

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