Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells.

@article{Wendt2008ConstitutiveCE,
  title={Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells.},
  author={Michael K Wendt and Luke J. Drury and Rebecca A. Vongsa and Michael B. Dwinell},
  journal={Gastroenterology},
  year={2008},
  volume={135 2},
  pages={508-17}
}
BACKGROUND & AIMS CXCL12 and CXCR4 signaling plays critical roles in development, homeostasis, and tumor metastasis. Previously, we have shown that epigenetic silencing of CXCL12 in colorectal and mammary carcinomas promotes metastasis. Anoikis is an essential process of colonic epithelial turnover and limits the metastatic progression of carcinoma. We sought to determine the role for anoikis in limiting tumor metastasis following reexpression of CXCL12 in human colorectal carcinoma cells… CONTINUE READING