Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

@article{Robey1994ConstitutiveCE,
  title={Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice},
  author={Ellen A. Robey and Andrea Itano and William Christian Fanslow and Jonathan Fowlkes},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={1997 - 2004}
}
Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to a CD4 or CD8 lineage is made without regard to the specificity of the TCR. According to this model, CD4+ cells with class I TCR do not mature because the CD8 coreceptor is required for class I MHC recognition and positive selection. If this… CONTINUE READING

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