Constitutional chromosome aberrations as pathogenetic events in hematologic malignancies.

@article{Welborn2004ConstitutionalCA,
  title={Constitutional chromosome aberrations as pathogenetic events in hematologic malignancies.},
  author={Jeanna Welborn},
  journal={Cancer genetics and cytogenetics},
  year={2004},
  volume={149 2},
  pages={137-53}
}
A predisposition to tumor development is associated with some constitutional chromosomal abnormalities. Investigations of families with an apparent hereditary cancer and constitutional chromosome rearrangements have led to the molecular identification of tumor suppressor genes. Under the somatic mutation theory for the development of cancer, two mutational events are required. The first step may be a constitutional event and the second an acquired genetic mutation. Cytogenetic studies were… CONTINUE READING