Constitutional aneuploidy and cancer predisposition.

  title={Constitutional aneuploidy and cancer predisposition.},
  author={Ithamar Ganmore and Gil Smooha and Shai Izraeli},
  journal={Human molecular genetics},
  volume={18 R1},
Constitutional aneuploidies are rare syndromes associated with multiple developmental abnormalities and the alterations in the risk for specific cancers. Acquired somatic chromosomal aneuploidies are the most common genetic aberrations in sporadic cancers. Thus studies of these rare constitutional aneuploidy syndromes are important not only for patient counseling and clinical management, but also for deciphering the mechanisms by which chromosomal aneuploidy affect cancer initiation and… CONTINUE READING

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