Constituents of the Roots and Leaves of Ekebergia capensis and Their Potential Antiplasmodial and Cytotoxic Activities

@inproceedings{Irungu2014ConstituentsOT,
  title={Constituents of the Roots and Leaves of Ekebergia capensis and Their Potential Antiplasmodial and Cytotoxic Activities},
  author={Beatrice N. Irungu and Jennifer A. Orwa and Amra Gruhonjic and Paul A Fitzpatrick and Goeran Landberg and Francis T. Kimani and Jacob Ogweno Midiwo and M{\'a}t{\'e} Erd{\'e}lyi and Abiy Yenesew},
  booktitle={Molecules},
  year={2014}
}
A new triterpenoid, 3-oxo-12β-hydroxy-oleanan-28,13β-olide (1), and six known triterpenoids 2-7 were isolated from the root bark of Ekebergia capensis, an African medicinal plant. A limonoid 8 and two glycoflavonoids 9-10 were found in its leaves. The metabolites were identified by NMR and MS analyses, and their cytotoxicity was evaluated against the mammalian African monkey kidney (vero), mouse breast cancer (4T1), human larynx carcinoma (HEp2) and human breast cancer (MDA-MB-231) cell lines… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Antiplasmodial triterpenoids from Ekebergia capensis.

  • Journal of natural products
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

12 α - Hydroxy - 3 , 27 - dioxooleanano - 28 , 13 - lactone

J. Hu, G. Wu, Y. Xu, G. Xiao, P. Lei
  • Acta Crystallogr . Sect . E
  • 2012