Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

  title={Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor},
  author={Rongxia Liu and Elke H. Heiss and Birgit Waltenberger and Tina Bla{\vz}evi{\'c} and Daniel Schachner and Bao-hong Jiang and Vladim{\'i}r Kry{\vs}tof and Wanhui Liu and Stefan Schwaiger and Luis Manuel Pe{\~n}a-Rodr{\'i}guez and Johannes M. Breuss and Hermann Stuppner and Verena M. Dirsch and Atanas Georgiev Atanasov},
  journal={Molecular Nutrition \& Food Research},
SCOPE Aberrant vascular smooth muscle cell (VSMC) proliferation is involved in atherosclerotic plaque formation and restenosis. Mediterranean spices have been reported to confer cardioprotection, but their direct influence on VSMCs has largely not been investigated. This study aims at examining rosmarinic acid (RA) and 11 related constituents for inhibition of VSMC proliferation in vitro, and at characterizing the most promising compound for their mode of action and influence on neointima… 

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