Constituents of Limonia acidissima inhibit LPS-induced nitric oxide production in BV-2 microglia

@article{HyunKim2010ConstituentsOL,
  title={Constituents of Limonia acidissima inhibit LPS-induced nitric oxide production in BV-2 microglia},
  author={Ki Hyun Kim and Sang Keun Ha and Sun Yeou Kim and Hyun Joo Youn and Kang Ro Lee},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  year={2010},
  volume={25},
  pages={887 - 892}
}
The ethyl acetate (EtOAc) soluble fraction of the 85% ethanol (EtOH) extract of the dried bark of Limonia acidissima potently inhibited nitric oxide (NO) production in lipopolysaccharide (LPS) activated BV-2 cells, a microglial cell line. Bioassay-guided column chromatography separation afforded a new stereoisomer of neolignan, (7’E)-(7R,8S)-4-hydroxy-3,5’-dimethoxy-4’,7-epoxy-8,3’-neolig-7’-en-9,9’-diyil diacetate (1), together with two known lignans, (+)-yangambin (2) and (+)-syringaresinol… 
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Three new benzamide derivatives, together with 10 known compounds, were isolated from the bark of Limonia acidissima and potently inhibited nitric oxide (NO) production in microglia cells.
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