Constituents of Limonia acidissima inhibit LPS-induced nitric oxide production in BV-2 microglia

  title={Constituents of Limonia acidissima inhibit LPS-induced nitric oxide production in BV-2 microglia},
  author={Ki Hyun Kim and Sang Keun Ha and Sun Yeou Kim and Hyun Joo Youn and Kang Ro Lee},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  pages={887 - 892}
The ethyl acetate (EtOAc) soluble fraction of the 85% ethanol (EtOH) extract of the dried bark of Limonia acidissima potently inhibited nitric oxide (NO) production in lipopolysaccharide (LPS) activated BV-2 cells, a microglial cell line. Bioassay-guided column chromatography separation afforded a new stereoisomer of neolignan, (7’E)-(7R,8S)-4-hydroxy-3,5’-dimethoxy-4’,7-epoxy-8,3’-neolig-7’-en-9,9’-diyil diacetate (1), together with two known lignans, (+)-yangambin (2) and (+)-syringaresinol… 
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Some of the acylated lignans (racemic mixtures) exhibited moderate inhibitory activities against Trypanosoma congolense, the causative agent of nagana disease in animals.
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Bioactive Compounds from Medicinal Plants in Myanmar.
  • N. Win, H. Morita
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    Progress in the chemistry of organic natural products
  • 2021
Phytochemical and biological investigations of these plants, including information on traditional knowledge are compiled and discussed and more than 433 phytoconstituents have been collated.


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Three new benzamide derivatives, together with 10 known compounds, were isolated from the bark of Limonia acidissima and potently inhibited nitric oxide (NO) production in microglia cells.
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Structures of 2, 3 and 4 were established by comparison of the spectral data with the previously reported compounds and the acid hydrolysate of 4 was identical with $3{\beta}-hydroxyolean-12-en-11-one$ (6).
Lignans of Rosa multiflora roots.
Five known lignans were isolated from the roots of Rosa multiflora for the first time and their structures were determined using spectroscopic data.
Dimeric phenolic constituents from the roots of Tamarix nilotica
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Non-alkaloidal constituents of Virola elongata bark
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