Constituents of Cannabis sativa L. IV. Stability of cannabinoids in stored plant material.

  title={Constituents of Cannabis sativa L. IV. Stability of cannabinoids in stored plant material.},
  author={Carlton E. Turner and K. W. Hadley and Patricia S. Fetterman and Norman J. Doorenbos and Maynard W. Quimby and Coy W. Waller},
  journal={Journal of pharmaceutical sciences},
  volume={62 10},
Abstract The (—)-∆ 9 - trans -tetrahydrocannabinol content of Cannabis sativa L. stored at — 18, 4, and 22 ± 1 ° decomposed at a rate of 3.83, 5.38, and 6.92%, respectively, per year, whereas the material stored at 37 and 50° showed considerable decomposition. C . satica L. stored in the absence of direct light at — 18, 4, and 22 ± 1 ° was more stable than cannabis stored under nitrogen. These data indicate that for normal research use, storage under nitrogen at 0° is not mandatory. Cannabinol… Expand
Constituents of Cannabis sativa L. XIII: Stability of dosage form prepared by impregnating synthetic (--)-delta 9-trans-tetrahydrocannabinol on placebo Cannabis plant material.
The amount of cannabinol observed when (--)-delta 9-trans-tetrahydrocannabinol decomposed indicates that cannabinol is not the only decomposition product. Expand
The stability of cannabis and its preparations on storage
It is concluded that carefully prepared herbal or resin cannabis or extracts are reasonably stable for 1 to 2 years if stored in the dark at room temperature. Expand
Long term stability of cannabis resin and cannabis extracts
The aim of the present study was to investigate the stability of cannabinoids in cannabis resin slabs and cannabis extracts upon long-term storage. The levels of tetrahydrocannabinol (THC),Expand
Stability of cannabinoids in hair samples exposed to sunlight.
A study was performed to elucidate whether cannabinoids such as THC, cannabinol (CBN), or cannabidiol (CBD), which usually are determined from hair samples, would exhibit similar instability in this particular biological matrix when exposed to solar radiation. Expand
Determination of the relative percentage distribution of THCA and Δ(9)-THC in herbal cannabis seized in Austria - Impact of different storage temperatures on stability.
It was shown successfully that high storage temperatures led to a more rapid and complete decomposition of THCA to Δ(9)-THC while at low temperatures only slight or no changes of the percentage distribution were determined. Expand
Cannabinoid stability in authentic oral fluid after controlled cannabis smoking.
Cannabinoids in expectorated OF were less stable than in Quantisal samples when refrigerated or frozen, and across participants. Expand
Stability of cannabinoids in dried samples of cannabis dating from around 1896-1905.
  • D. Harvey
  • Chemistry, Medicine
  • Journal of ethnopharmacology
  • 1990
The results suggest that decomposition of cannabis samples may proceed more slowly than originally thought. Expand
Cannabis sativa L.: Botany and Horticulture
In this chapter, the focus is laid on the botanical aspects of C. sativa and its cultivation for phytopharmaceuticals. Expand
Biological Activity of Cannabichromene, its Homologs and Isomers
Cannabichromene is one of four major cannabinoids in Cannabis sativa L. and is the second most abundant cannabinoid in drug‐type cannabis andAntibacterial activity was strong, and the antifungal activity was mild to moderate. Expand
Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis
This review discusses the chemistry of the cannabinoids and major non-cannabinoid constituents (terpenes, non-Cannabinoid phenolics, and alkaloids) with special emphasis on their chemical structures, methods of isolation, and identification. Expand


Mississippi-grown Cannabis sativa L: preliminary observation on chemical definition of phenotype and variations in tetrahydrocannabinol content versus age, sex, and plant part.
Nine strains of Cannabis sativa L. sativa (marijuana) were grown for research by the University of Mississippi and the cannabinoid content was determined using GLC, and the material was divided into two chemical phenotypes according to cannabinoid content. Expand
Classical studies of the resinous cannabinoid fraction of the plant by Adams,’ Todd,2 and Cahn3 and more recently by T a y l ~ r , ~ M e c h o ~ l a m , ~ and their COworkers led to the definitiveExpand
The identification, isolation, and preservation of Δ9‐tetrahydrocannabinol (Δ9‐THC) * , †
(—)‐trans‐Δ9‐Tetrahydrocannabinol (Δ9‐THC) was isolated from marihuana plant extract, by adsorptive column and glc. The adsorptive column chromatography method consisted of chromatographing marihuanaExpand
Constituents of Cannabis sativa L. 3. Clear and discrete separation of cannabidiol and cannabichromene.
Synthetic cannabidiol and cannabichromene were discretely separated by GLC using their trimethylsilyl ether derivatives. The mono and disilylated derivatives of cannabidiol were identified. ThisExpand
Origin of cannabinol