Constipation: Advances in Diagnosis and Treatment.

@article{Wald2016ConstipationAI,
  title={Constipation: Advances in Diagnosis and Treatment.},
  author={Alexandra Wald},
  journal={JAMA},
  year={2016},
  volume={315 2},
  pages={
          185-91
        }
}
IMPORTANCE Chronic constipation accounts for at least 8 million annual visits to health care providers in the United States and is associated with large expenditures for diagnostic testing and prescription and nonprescription laxatives. OBSERVATIONS Strong evidence for efficacy has been established for stimulant and osmotic laxatives, new intestinal secretogogues, and peripherally restricted μ-opiate receptor antagonists, the latter a major advance in the treatment of opioid-induced… CONTINUE READING
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