Constant-rate drug release from novel anionic gel beads with transient composite structure.

  • Ping I Lee
  • Published 1993 in Journal of pharmaceutical sciences


A new anionic composite bead system with a transient membrane-matrix structure, capable of prolonged constant-rate drug release, has been developed from suspension-polymerized poly(methyl methacrylate-co-methacrylic acid) (PMMA/MAA). These composite beads have a thin PMMA/MAA surface layer and a core consisting of the sodium salt form of the polymer (PMMA… (More)


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