Consomic rat model systems for physiological genomics.

  title={Consomic rat model systems for physiological genomics.},
  author={Allen W. Cowley and Manzhong Liang and Richard J. Roman and Andrew S. Greene and Howard J. Jacob},
  journal={Acta physiologica Scandinavica},
  volume={181 4},
A consomic rat strain is one in which an entire chromosome is introgressed into the isogenic background of another inbred strain using marker-assisted selection. The development and physiological screening of two inbred consomic rat panels on two genetic backgrounds (44 strains) is well underway. Consomic strains enable one to assign traits and quantitative trait loci (QTL) to chromosomes by surveying the panel of strains with substituted chromosomes. They enable the rapid development of… CONTINUE READING

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