Consolidated bioprocessing of cellulose to isobutanol using Clostridium thermocellum.

  title={Consolidated bioprocessing of cellulose to isobutanol using Clostridium thermocellum.},
  author={Paul P. Lin and Luo Mi and Amy H Morioka and Kouki M Yoshino and Sawako Konishi and Sharon C. Xu and Beth A Papanek and Lauren A Riley and Adam M Guss and James C. Liao},
  journal={Metabolic engineering},
Consolidated bioprocessing (CBP) has the potential to reduce biofuel or biochemical production costs by processing cellulose hydrolysis and fermentation simultaneously without the addition of pre-manufactured cellulases. In particular, Clostridium thermocellum is a promising thermophilic CBP host because of its high cellulose decomposition rate. Here we report the engineering of C. thermocellum to produce isobutanol. Metabolic engineering for isobutanol production in C. thermocellum is hampered… CONTINUE READING
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