Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity.

@article{Wang1995ConsistentPO,
  title={Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity.},
  author={C. C. Wang and H F Tien and Ming-Hsien Lin and I. J. Su and C. H. Wang and Shu Mien Chuang and M C Shen and Catherine H. Liu},
  journal={Genes, chromosomes & cancer},
  year={1995},
  volume={12 3},
  pages={161-4}
}
Peripheral T-cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the gamma/delta T-cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T gamma/delta cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8… CONTINUE READING