Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts.

@article{Narita1999ConsistentDO,
  title={Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts.},
  author={Mitsuo Narita and Kimiko Shimizu and Yasuhide Hayashi and Tomohiko Taki and Masafumi Taniwaki and F. Hosoda and Hirofumi Kobayashi and Hideo Nakamura and Naoki Sadamori and Hiroaki Ohnishi and Fumio Bessho and Masayoshi Yanagisawa and M. Ohki},
  journal={British journal of haematology},
  year={1999},
  volume={105 4},
  pages={928-37}
}
The t(10;11)(p13-14;q14-21) is a rare but recurring translocation associated with acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). Recently the CALM gene was cloned from the t(10;11) breakpoint of U937 and fused to AF10, a putative transcription factor, which had been identified as one of the fusion partners of the MLL gene. In order to define the involvement of these genes in primary leukaemias and cell lines with t(10;11), we analysed the expression of fusion transcripts… CONTINUE READING

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