Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21.

Abstract

PURPOSE Melanomas, sarcomas, and neuroblastomas abundantly express the ganglioside GD2 on the cell surface where it is susceptible to immune attack by antibodies. Overexpression of GD2 on these tumors is striking, as is the frequency of clinical responses after treatment of neuroblastoma with monoclonal antibodies against GD2. In addition, preclinical… (More)

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@article{Ragupathi2003ConsistentAR, title={Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21.}, author={Govindaswami Ragupathi and Philip O. Livingston and Chandra Hood and John K Gathuru and Susan E. Krown and Paul B Chapman and Jedd D Wolchok and Linda J. Williams and Roberta C Oldfield and Wen-Jen Hwu}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2003}, volume={9 14}, pages={5214-20} }