Consistent and Selective Expression of the Discoidin Domain Receptor-1 Tyrosine Kinase in Human Brain Tumors

@article{Weiner2000ConsistentAS,
  title={Consistent and Selective Expression of the Discoidin Domain Receptor-1 Tyrosine Kinase in Human Brain Tumors},
  author={Howard L. Weiner and H J Huang and David Zagzag and Hayden Boyce and Roger Lichtenbaum and Edward Benjamin Ziff},
  journal={Neurosurgery},
  year={2000},
  volume={47},
  pages={1400-1409}
}
OBJECTIVEFew molecular targets are both consistently and selectively expressed in a majority of central nervous system (CNS) neoplasms. Receptor tyrosine kinases have been implicated in brain tumor oncogenesis. We previously isolated one such receptor, discoidin domain receptor-1 (DDR1), from high-grade pediatric brain tumors. Here, we analyze the cellular origin and distribution of DDR1 expression in human brain tumors and its expression in tumor cells relative to surrounding brain. METHODSBy… 
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