Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis

@article{He2018ConsistentAO,
  title={Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis},
  author={Xin He and Zongguo Pang and Xian-liang Zhang and Ting Lan and Hui-jiao Chen and Min Chen and Hong Yang and Juan Huang and Yihua Chen and Zhang Zhang and Wenyi Jing and Ran Peng and Hongying Zhang},
  journal={The American Journal of Surgical Pathology},
  year={2018},
  volume={42},
  pages={1143–1155}
}
Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS). LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4. Recent studies identified consistent amplification of FRS2 gene in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma. The aim of this… 
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