Consistency of safety profile of new oral anticoagulants in patients with renal failure.

@article{Lega2014ConsistencyOS,
  title={Consistency of safety profile of new oral anticoagulants in patients with renal failure.},
  author={Jean-christophe Lega and Laurent Bertoletti and Cyrielle Gremillet and Christian Boissier and Patrick Mismetti and Silvy Laporte},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 3},
  pages={
          337-43
        }
}
BACKGROUND The use of new oral anticoagulants (NOACs) in patients with impaired renal function has raised major concerns, in particular the possibility of an increased risk of bleeding due to accumulation. The aims of this work were to assess the safety of NOACs in patients with renal failure and describe the relationship between clinical events and drug renal excretion magnitude. METHODS All phase III trials comparing NOACs with vitamin K antagonists (VKAs) in patients with estimated… CONTINUE READING
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