Considering sex as a biological variable will require a global shift in science culture.

@article{Shansky2021ConsideringSA,
  title={Considering sex as a biological variable will require a global shift in science culture.},
  author={Rebecca M. Shansky and Anne Z. Murphy},
  journal={Nature neuroscience},
  year={2021}
}
For over half a century, male rodents have been the default model organism in preclinical neuroscience research, a convention that has likely contributed to higher rates of misdiagnosis and adverse side effects from drug treatment in women. Studying both sexes could help to rectify these public health problems, but incentive structures in publishing and career advancement deter many researchers from doing so. Moreover, funding agency directives to include male and female animals and human… 
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References

SHOWING 1-10 OF 88 REFERENCES
Sex bias in neuroscience and biomedical research
Considering sex as a biological variable in preclinical research
TLDR
This article is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.
Are hormones a “female problem” for animal research?
TLDR
Outdated gender stereotypes are influencing experimental design in laboratory animals and shapes not just how society perceives women but also how biomedical scientists approach animal research.
Sex differences in behavioral strategies: avoiding interpretational pitfalls
  • R. Shansky
  • Psychology, Biology
    Current Opinion in Neurobiology
  • 2018
Sex as a Biological Variable: A 5-Year Progress Report and Call to Action.
TLDR
It is found that the application of SABV throughout the research process can serve as a guiding principle to improve the value of biomedical science and call on NIH's various stakeholders to redouble their efforts to integrate SABv throughout the biomedical research enterprise.
Studying both sexes: a guiding principle for biomedicine
  • J. Clayton
  • Medicine, Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2016
TLDR
The rationale behind the SABV policy component is described and the practice of studying both sexes in preclinical research will expand the currently incomplete knowledge base that plays a critical role in informing the development of sex‐and gender‐appropriate medical care for women and men.
Why sex matters for neuroscience
  • L. Cahill
  • Psychology
    Nature Reviews Neuroscience
  • 2006
TLDR
The striking quantity and diversity of sex-related influences on brain function indicate that the still widespread assumption that sex influences are negligible cannot be justified, and probably retards progress in the field.
Minireview: Sex differences in adult and developing brains: compensation, compensation, compensation.
TLDR
This review will entertain the possibility that transient sex differences in gene expression in developing brains may cause permanent differences in brain structure but prevent them as well, by compensating for potentially differentiating effects ofsex differences in gonadal hormone levels and sex chromosomal gene expression.
A 10-year follow-up study of sex inclusion in the biological sciences
TLDR
A bibliometric analysis across nine biological disciplines for papers published in 34 journals in 2019 demonstrates that while sex-inclusive research practices are more commonplace, there are still gaps in analyses and reporting of data by sex in many biological disciplines.
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