Considering dependence among genes and markers for false discovery control in eQTL mapping

@article{Chen2008ConsideringDA,
  title={Considering dependence among genes and markers for false discovery control in eQTL mapping},
  author={Liang Jeff Chen and Tiejun Tong and Hongyu Zhao},
  journal={Bioinformatics},
  year={2008},
  volume={24 18},
  pages={
          2015-22
        }
}
MOTIVATION Multiple comparison adjustment is a significant and challenging statistical issue in large-scale biological studies. In previous studies, dependence among genes is largely ignored. However, such dependence may be strong for some genomic-scale studies such as genetical genomics [also called expression quantitative trait loci (eQTL) mapping] in which thousands of genes are treated as quantitative traits and mapped to different genetical markers. Besides the dependence among markers… CONTINUE READING

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