Considering aspects of the 3Rs principles within experimental animal biology

  title={Considering aspects of the 3Rs principles within experimental animal biology},
  author={Lynne U. Sneddon and Lewis G. Halsey and Nicolas R. Bury},
  journal={Journal of Experimental Biology},
  pages={3007 - 3016}
ABSTRACT The 3Rs – Replacement, Reduction and Refinement – are embedded into the legislation and guidelines governing the ethics of animal use in experiments. Here, we consider the advantages of adopting key aspects of the 3Rs into experimental biology, represented mainly by the fields of animal behaviour, neurobiology, physiology, toxicology and biomechanics. Replacing protected animals with less sentient forms or species, cells, tissues or computer modelling approaches has been broadly… 

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