Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions?

@article{Hoffmann1997ConsiderationsOT,
  title={Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions?},
  author={Aa Hoffmann and Thomas Oelgeschl{\"a}ger and Robert G. Roeder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 17},
  pages={
          8928-35
        }
}
  • Aa Hoffmann, Thomas Oelgeschläger, Robert G. Roeder
  • Published 1997
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • The general transcription initiation factor TFIID was originally identified, purified, and characterized with a biochemical assay in which accurate transcription initiation is reconstituted with multiple, chromatographically separable activities. Biochemical analyses have demonstrated that TFIID is a multiprotein complex that directs preinitiation complex assembly on both TATA box-containing and TATA-less promoters, and some TFIID subunits have been shown to be molecular targets for activation… CONTINUE READING

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