Considerations in the Identification of Endogenous Substrates for Protein L-Isoaspartyl Methyltransferase: The Case of Synuclein

Abstract

Protein L-isoaspartyl methyltransferase (PIMT) repairs abnormal isoaspartyl peptide bonds in age-damaged proteins. It has been reported that synuclein, a protein implicated in neurodegenerative diseases, is a major target of PIMT in mouse brain. To extend this finding and explore its possible relevance to neurodegenerative diseases, we attempted to… (More)
DOI: 10.1371/journal.pone.0043288

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