Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic.

@article{Arnett2007ConsiderationsFT,
  title={Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic.},
  author={Heather A. Arnett and Joanne L. Viney},
  journal={Advanced drug delivery reviews},
  year={2007},
  volume={59 11},
  pages={1084-92}
}
Successful therapeutics for treating autoimmune and inflammatory diseases must be able to significantly dampen, and ideally reverse, the complex processes involved in the manifestation of inflammatory pathology in intact tissues and organs. Studies on human cells and tissues - both normal and diseased - are obviously critical for moving forward with a particular therapeutic strategy, but these types of studies are oftentimes limited in their complexity and usually fail to fully replicate the… CONTINUE READING

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