Considerations for the clinical development of cytokine gene-transduced tumor cell vaccines.

@article{Jaffee1997ConsiderationsFT,
  title={Considerations for the clinical development of cytokine gene-transduced tumor cell vaccines.},
  author={Elizabeth M. Jaffee and Drew Mark Pardoll},
  journal={Methods},
  year={1997},
  volume={12 2},
  pages={
          143-53
        }
}
In preclinical models, tumor cells genetically altered to secrete cytokines or express costimulatory molecules can generate systemic antitumor immunity. In some studies, these tumor vaccines have been shown to eradicate micrometastases. These results have led to the initiation of numerous phase I clinical trials employing either genetically modified or allogenic tumor vaccines. This article addresses a number of issues related to the clinical development of cytokine gene-transduced tumor cell… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Progress and challenges in the vaccine-based treatment of head and neck cancers

Journal of experimental & clinical cancer research : CR • 2009
View 2 Excerpts

Anticancer effect of a lentiviral vector capable of expressing HIV-1 Vpr.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2001