Considerations for the Use of Polysorbates in Biopharmaceuticals

  title={Considerations for the Use of Polysorbates in Biopharmaceuticals},
  author={Michael T Jones and H. Mahler and Sandeep Kumar Yadav and Dilbir S. Bindra and Vincent Corvari and R. Matthew Fesinmeyer and Kapil Gupta and Alexander M Harmon and Kenneth D Hinds and Atanas V. Koulov and Wei Liu and Kevin M Maloney and John Wang and Ping Y Yeh and Satish Kumar Singh},
  journal={Pharmaceutical Research},
Polysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in protein formulations. Based on this knowledge, a development strategy is proposed that leads to a control strategy for polysorbates… CONTINUE READING

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